The Application of Probiotics in Gastrointestinal Diseases

Inflammatory Bowel Disease (IBD) and other gastrointestinal disorders are now a major worldwide health burden. The pathophysiology of these illnesses is significantly influenced by disruptions in the gut flora. Beneficial microorganisms known as probiotics have the potential to improve health by balancing the microbiota and influencing immune responses. This review explores the mechanisms of action of selected probiotic strains, including Lactobacillus rhamnosus, Lactobacillus plantarum, and E. coli Nissle 1917. We conducted a systematic review of relevant literature to evaluate the safety and efficacy of these probiotics in treating gastrointestinal disorders. These strains have demonstrated promising effects in regulating inflammation, improving gut barrier function, and modulating immune responses. In each individual case, all of the probiotic strains have shown signs of improving the gut microbiota as well as inhibiting key inflammatory pathways and reducing inflammation through reduction in intensity (L.Rhamnosus), fecal composition (L.Plantarum L-137) as well as IBDQ (E.coli Nissle).