Visualization Analysis of International Polygenic Risk Scores Based on CiteSpace

Objective: Over the past two decades, polygenic risk scores (PRS) have made significant advancements in predicting the risk and aiding in the precision prevention of complex diseases. This study conducts a visualization analysis of literature in this field to explore its current development, hotspots, and trends, providing a reference for further PRS research. Methods: We retrieved relevant literature on polygenic scoring from the Web of Science database and performed a visual analysis using the CiteSpace software, examining publication volume, authors, and institutional collaboration. Results: A total of 8,433 articles were retrieved, and 4,499 were included after manual selection. Overall, publication volume showed an upward trend; the most prolific author was Brenner, Hermann, with 61 publications; Harvard University ranked as the top institution in terms of publication volume; and the United States was the leading country in terms of output. High-frequency keywords included genome-wide association. Conclusion: Collaboration among scholars and institutions is relatively limited, suggesting the need for strengthened cooperation. Relevant domestic studies are few, while international research hotspots mainly focus on schizophrenia, coronary heart disease, and Alzheimers disease, providing a reference for PRS research in China.