The main methods and application prospects of treating cancer through the induction of ferroptosis

The highly deadly illness known as cancer is brought on by the malignant growth of cells, and it ranks among the top causes of death globally at the moment.In recent years, research on cancer treatment drugs has emerged one after another. However, due to the continuous mutation of cancer cells, they develop resistance to traditional anti-cancer drugs, making it even more difficult to achieve a complete cure for cancer.Recent experimental studies have shown that ferroptosis,a non-apoptotic cell death pathway triggered by iron, can effectively overcome issues such as drug resistance in cancer cells, thereby achieving effective treatment for cancer. It is currently a promising therapeutic approach, and many researchers have been investigating iron death induction treatment methods.And alarge number of research papers on this novel cancer treatment method known as ferroptosis have been published.This review summarizes and introduces two treatment methods based on ferroptosis that have been extensively researched, which called therapeutic method for inducing ferroptosis using targeted nanoparticles and Methods for combining immunity and ferroptosis.,and analyzing their development prospects as well as some issues currently faced in research and suggestions for future development directions.