Exploring the role of circadian rhythms in Polycystic Ovary Syndrome

Polycystic Ovary Syndrome (PCOS) impacts 7% of women of reproductive age and is linked to metabolic syndrome, diabetes, cardiovascular conditions, and more. There hasn't been an exact explanation for the cause of this disease. Despite extensive research, the complete pathophysiology of PCOS remains elusive. One intriguing avenue of investigation is the association between PCOS and circadian rhythms. Sleep disorders, a symptom of PCOS, is controlled by circadian rhythms. Women with PCOS have been proven to suffer from sleep disorders, indicating a relation between the two. Furthermore, studies have shown that PCOS affects the endocrine system, which is vital in regulating circadian rhythms. Numerous studies have been done on the relationship between PCOS and circadian rhythms on a genetic level, where Cytochrome P450(CYP) genes and CLOCK genes are affected by PCOS pathogenesis. The regulation of circadian rhythms plays a positive role in the mitigation and treatment of PCOS. The physiological connections between PCOS and circadian clocks are presented in this review. It draws attention to the most recent studies on the relationships between circadian disorders and PCOS, which suggest a possible explanation and alleviation for the syndrome.