CAR-T cells are more affected than T lymphocytes by mechanical constraints: A microfluidic-based approach
Our approach contributes to a better understanding of immune cell migration and the influence of mechanical constraints, which will allow the testing of new ways to improve CAR-T cell trafficking into solid tumours. Therefore, our study revealed that the migratory behaviour of CAR-T cells differs from that of T cells under confined conditions and that biomechanical cues, such as cell deformability caused by confinement, can influence the correct infiltration of immune cells into solid tumours during the immune response.
Authors
- María José Gómez‐Benito (ORCID: https://orcid.org/0000-0002-1878-8997)
- José Manuel García‐Aznar (ORCID: https://orcid.org/0000-0002-9864-7683)
- Julián Pardo Jimeno
- Pedro Enrique Guerrero (ORCID: https://orcid.org/0000-0003-2612-9235)
- Nieves Movilla Meno
- Carmen Oñate Salafranca
- Jack Zhang-Zhou
Institutions
- Universidad de Zaragoza (ES)
- Instituto de Nanociencia y Materiales de Aragón (ES)
- Instituto de Investigación Sanitaria Aragón (ES)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1016/j.lfs.2024.123335
- Citations
- 6
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- European Commission
- Ministerio de Ciencia e Innovación
- Gobierno de Aragón
- Ministerio de Educación y Formación Profesional
- European Research Council
- Horizon 2020
- European Regional Development Fund
- Agencia Estatal de Investigación