Real-World Outcomes in Cardiac Resynchronization Therapy Patients: Primary Results of the SMART Registry

This large, global registry enrolled a CRT-D population with higher incidence of comorbidities that have been historically underrepresented in clinical trials and provides new insight into factors influencing response to CRT. As defined by CCS, 58.9% of patients improved and 20.1% stabilized. Patients with AF had particularly worse clinical outcomes, higher HF hospitalization and mortality rates and lower percentages of ventricular pacing. High incidence of HF hospitalization in patients with AF and non-LBBB in this real-world cohort suggests that ablation may play an important role in increasing future CRT response rates.

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Publication Details

Journal
ESC Heart Failure
Published
2024-12-26
DOI
https://doi.org/10.1002/ehf2.15190
Primary Topic
Cardiac pacing and defibrillation studies
Type
article
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article

Real-World Outcomes in Cardiac Resynchronization Therapy Patients: Primary Results of the SMART Registry

Nicolas Lellouche, E. W. Chew, Daniel Gras, Matteo Bertini et al.
ESC Heart Failure
Cardiac pacing and defibrillation studies
article

Real-World Outcomes in Cardiac Resynchronization Therapy Patients: Primary Results of the SMART Registry

Nicolas Lellouche, E. W. Chew, Daniel Gras, Matteo Bertini, Ignacio Garcı́a-Bolao, Sara Veraghtert, Roy S. Gardner, Michelle M. Harbin, Elizabeth Matznick, David J. Wright, Patrick Yong, Devi G. Nair, Antonio D’Onofrio, Miroslav Novák, Ronald Lo, Andrew J. Kaplan, Kenneth M. Steín, George E. Mark
article en

Abstract

This large, global registry enrolled a CRT-D population with higher incidence of comorbidities that have been historically underrepresented in clinical trials and provides new insight into factors influencing response to CRT. As defined by CCS, 58.9% of patients improved and 20.1% stabilized. Patients with AF had particularly worse clinical outcomes, higher HF hospitalization and mortality rates and lower percentages of ventricular pacing. High incidence of HF hospitalization in patients with AF and non-LBBB in this real-world cohort suggests that ablation may play an important role in increasing future CRT response rates.

ESC Heart FailureVol. 12(3)
University of Ulster (GB), University of Liverpool (GB), Loma Linda University (US), Golden Jubilee National Hospital (GB), Belfast City Hospital (GB), Boston Scientific (United States) (US), University Reproductive Associates (US), Liverpool Heart and Chest Hospital (GB), Assistance Publique – Hôpitaux de Paris (FR), Azienda Unità Sanitaria Locale di Ferrara (IT), Arcispedale Sant'Anna (IT), Middle East Studies Association of North America (US), Clinica Universidad de Navarra (ES), Hôpital privé du Confluent (FR), St. Anne's University Hospital Brno (CZ), Cardiovascular Research Associates (US), Ospedale Monaldi (IT), VA Loma Linda Healthcare System (US), Arkansas Biosciences Institute (US)
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Openalex Percentile: Top 56%
Cardiac pacing and defibrillation studies
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