E. coli Nissle 1917 improves gut microbiota composition and serum metabolites to counteract atherosclerosis via the homocitrulline/Caspase 1/NLRP3/GSDMD axis
EcN could alleviate atherosclerosis development by ameliorating HFD-induced disorders of gut microbiota and serum metabolites (such as homocitrulline) to alleviate pyroptosis, which may be associated with homocitrulline/Caspase 1/NLRP3/GSDMD axis. Our study lays the foundation for the development of promising drugs for atherosclerosis in the future.
Authors
- Zhixiang Zhou
- Xuefeng Yang (ORCID: https://orcid.org/0000-0002-1555-4087)
- Sujun Xiao
- Zhi‐Sheng Jiang (ORCID: https://orcid.org/0000-0002-9044-3491)
- Huan Liu (ORCID: https://orcid.org/0000-0002-9947-6687)
- Shao Ouyang
- Zhihao Hu (ORCID: https://orcid.org/0000-0003-0966-9766)
- Xiaofeng Ma (ORCID: https://orcid.org/0009-0009-0302-6023)
Institutions
- University of South China (CN)
Publication Details
- Journal
- International Journal of Medical Microbiology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1016/j.ijmm.2024.151642
- Citations
- 7
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.64