Benzaldehyde and azaphilone derivatives from the marine-derived fungus <i>Penicillium sclerotiorum</i> PSU-AMF89

Two new compounds including one benzaldehyde (<b>1</b>) and one azaphilone (<b>2</b>) were isolated from the marine-derived fungus <i>Penicillium sclerotiorum</i> PSU-AMF89 together with nine known compounds (<b>3</b>-<b>11</b>). Their structures were determined by spectroscopic evidences. The absolute configuration of <b>2</b> was established by comparison of the ECD data with those of the previously reported data of compound <b>7</b> as well as the biosynthetic consideration. Compound <b>1</b> displayed potent cytotoxic activity against MCF-7 cells with an IC₅₀ value of 9 <i>µ</i>M, compared with the standard drugs, tamoxifen and doxorubicin, whereas compounds <b>3</b> and <b>8</b> were moderately active against <i>Cryptococcus neoformans</i> and methicillin-resistant <i>Staphylococcus aureus</i>, respectively, with equal MIC values of 64 <i>µ</i>g/mL. In addition, they were non-cytotoxic to noncancerous Vero cells.