The modified role including mediating and synergistic interactive effects of glucose tolerance status in the associations between relative fat mass and the risks of cardiovascular disease and all-cause mortality from the 4C cohort study
RFM was associated with increased risk of fatal, nonfatal CVD events, and all-cause mortality in NGT, prediabetes, and diabetes, and these associations were modified by glucose tolerance status, which could significantly influence how clinicians assess high risk and could lead to more personalized, effective prevention strategies.
Authors
- Danpei Li (ORCID: https://orcid.org/0000-0003-4972-976X)
- Xiaoyu Meng (ORCID: https://orcid.org/0000-0002-5239-6866)
- Yaming Guo
- Xuefeng Yu (ORCID: https://orcid.org/0000-0003-3961-9321)
- Peiqiong Luo (ORCID: https://orcid.org/0009-0000-2712-5856)
- Ranran Kan (ORCID: https://orcid.org/0009-0001-2829-945X)
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s13098-024-01558-8
- Citations
- 2
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Natural Science Foundation of China