Genetic Variants Associated With Preeclampsia and Maternal Serum sFLT1 Levels
The current data are consistent with a causal association between sFLT1 released by the placenta in late pregnancy and the pathophysiology of preeclampsia. The data are also consistent with maternal components to the protective effect of high sFLT1 in the first trimester and the rise in third-trimester sFLT1 levels and preeclampsia.
Authors
- Gaganjit K. Madhan (ORCID: https://orcid.org/0000-0002-7553-351X)
- Emma Cook (ORCID: https://orcid.org/0000-0002-6142-4443)
- Francesca Gaccioli (ORCID: https://orcid.org/0000-0001-7178-8921)
- D. Stephen Charnock‐Jones (ORCID: https://orcid.org/0000-0002-2936-4890)
- Jasmine A. Mack (ORCID: https://orcid.org/0000-0001-7343-0579)
- John R. B. Perry (ORCID: https://orcid.org/0000-0001-6483-3771)
- Ulla Sovio (ORCID: https://orcid.org/0000-0002-0799-1105)
- Alison A. Motsinger‐Reif (ORCID: https://orcid.org/0000-0003-1346-2493)
- Felix R. Day (ORCID: https://orcid.org/0000-0003-3789-7651)
- Nadua Bayzid (ORCID: https://orcid.org/0000-0002-7209-9471)
- Marius Cotic (ORCID: https://orcid.org/0000-0002-1481-9100)
- Gordon C. S. Smith (ORCID: https://orcid.org/0000-0003-2124-0997)
- Nathan Dunton (ORCID: https://orcid.org/0009-0001-1696-7748)
Institutions
- Society for Neuroscience (US)
- University of Cambridge (GB)
- Cambridge School (PT)
- National Institute of Environmental Health Sciences (US)
- Wellcome/MRC Institute of Metabolic Science (GB)
- Institut thématique Génétique, génomique et bioinformatique (FR)
- National Institute of Health (AM)
- Genomics England (GB)
- MRC Epidemiology Unit (GB)
- University College London (GB)
Publication Details
- Journal
- Hypertension
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23400
- Citations
- 7
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 4.08