Penetration of linezolid into the pleural cavity in critically ill patients with proven or suspected Gram-positive bacterial infections: a retrospective pharmacokinetic study
Linezolid seems to penetrate well into the PF, with concentrations exceeding those in plasma. However, high inter-individual variability, both in plasma and PF concentrations, was observed. A high proportion of patients did not achieve the PK/PD target in plasma, especially in the presence of high MIC strains.
Authors
- Joan Ramon Masclans-Enviz
- Juan Pablo Horcajada (ORCID: https://orcid.org/0000-0001-9873-5459)
- Santiago Grau (ORCID: https://orcid.org/0000-0002-8428-1836)
- Sònia Luque (ORCID: https://orcid.org/0000-0002-3215-320X)
- Marta de Antonio-Cuscó (ORCID: https://orcid.org/0000-0003-0408-6182)
- Luisa Sorlí (ORCID: https://orcid.org/0000-0001-9562-514X)
- Rosana Muñoz-Bermúdez (ORCID: https://orcid.org/0000-0002-9210-3976)
- Carlos López-Mula
- Núria Prim
- M.P. Gracia-Arnillas
- Núria Campillo Ambrós
Institutions
- Universitat Pompeu Fabra (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Del Mar (ES)
- Hospital Can Misses (ES)
- Hospital del Mar Research Institute (ES)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1093/jac/dkae444
- Citations
- 2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.90