Chronic intermittent hypobaric hypoxia alleviates early-stage posttraumatic osteoarthritis via NF-κB/Nrf2 pathway in mice
Our study demonstrated that immediate CIHH treatment following cartilage injury initiation can attenuate load-induced cartilage damage by activating Nrf2/HO-1 and inhibiting the NF-κB p65 signalling pathways to counteract oxidative stress and inflammatory reactions, enhance the metabolic balance of the cartilage matrix and delay cartilage degeneration. This treatment may represent a potential therapeutic strategy for limiting PTOA progression.
Authors
- Zhenhua Shi (ORCID: https://orcid.org/0000-0001-7308-3239)
- Guowei Ren
- Shuangquan Yao (ORCID: https://orcid.org/0000-0002-4442-8952)
- Lindan Geng (ORCID: https://orcid.org/0009-0005-5398-1636)
- Pengcheng Wang (ORCID: https://orcid.org/0000-0001-9626-6978)
- Dong Ren (ORCID: https://orcid.org/0000-0002-1790-3279)
- Haowei Hou
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei Normal University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s13018-024-05376-6
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Health Commission of Hebei Province
- Hebei Provincial Department of Bureau of Science and Technology