High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension
Pathological HSS reduced lung EC ERG, resulting in EndMT and PAH. Agents that upregulate ERG could reverse HSS-mediated PAH and occlusive vascular remodeling resulting from high flow or narrowed PAs.
Authors
- Cholawat Pacharinsak (ORCID: https://orcid.org/0009-0001-2589-1992)
- Aiqin Cao
- Yoon Hong Chun (ORCID: https://orcid.org/0000-0002-9871-5244)
- Jason M. Szafron (ORCID: https://orcid.org/0000-0001-9476-5175)
- Shinji Saitoh (ORCID: https://orcid.org/0000-0001-6911-3351)
- Jakob Körbelin (ORCID: https://orcid.org/0000-0002-5435-7182)
- Divya Guntur
- Jordan Kaplan (ORCID: https://orcid.org/0000-0002-2288-2556)
- Marlene Rabinovitch (ORCID: https://orcid.org/0000-0001-7886-7104)
- Yoshihide Mitani (ORCID: https://orcid.org/0000-0002-6038-8161)
- Laura Pisani (ORCID: https://orcid.org/0000-0003-3084-3300)
- Sarasa Isobe (ORCID: https://orcid.org/0000-0002-7405-0903)
- Shalina Taylor (ORCID: https://orcid.org/0000-0002-5573-6483)
- Jan-Renier Moonen (ORCID: https://orcid.org/0000-0002-0361-824X)
- Kenichi Okamura (ORCID: https://orcid.org/0000-0001-9205-3457)
- Weiguang Yang (ORCID: https://orcid.org/0000-0003-3324-4346)
- Melody Dong (ORCID: https://orcid.org/0000-0001-7791-5012)
- Tsutomu Shinohara (ORCID: https://orcid.org/0000-0002-0697-5568)
- Alison L. Marsden (ORCID: https://orcid.org/0000-0003-1902-171X)
- Katherine Guo
- Yannick C. Lee-Yow (ORCID: https://orcid.org/0000-0002-9642-9121)
- Lingli Wang (ORCID: https://orcid.org/0000-0003-2756-5346)
- Benjamin D. Franco
- J Engreitz (ORCID: https://orcid.org/0000-0002-5754-1719)
Institutions
- Lucile Packard Children's Hospital (US)
- Universität Hamburg (DE)
- Mie University (JP)
- Medical University of Graz (AT)
- Cardiovascular Institute of the South (US)
- Nagoya City University (JP)
- St. Mary's Hospital (US)
- The Catholic University of Korea Incheon St. Mary's Hospital (KR)
- University Medical Center Hamburg-Eppendorf (DE)
- Maine Farmland Trust (US)
- La Jolla Bioengineering Institute (US)
- St. Mary’s Hospital (ZA)
- Institute of Genetics (CA)
- National Defense Medical College (JP)
- Carnegie Mellon University (US)
- Stanford University (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1161/atvbaha.124.321092
- Citations
- 10
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.19