Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy
LD formation is a feedback response to IC2's anti-tumor effects, which compromises the anti-tumor actions. IC2's anti-tumor efficacy can be enhanced by combining it with inhibitors targeting LD formation. This strategy may be extended to other anti-tumor agents that regulate lipid metabolism.
Authors
- Zengwei Lai (ORCID: https://orcid.org/0000-0001-7684-1154)
- Sitao Chen (ORCID: https://orcid.org/0009-0000-8913-6059)
- Yang Chen (ORCID: https://orcid.org/0000-0003-2762-7543)
- Ninghan Feng (ORCID: https://orcid.org/0000-0002-0892-6102)
- Yunjun Ge (ORCID: https://orcid.org/0000-0002-2405-2281)
- Yi-Yuan Jin
- Guosheng Wu
- Ying Liang
- He Xiong
- Jie Wang (ORCID: https://orcid.org/0000-0001-5442-9505)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5975-9781)
Institutions
- Jiangnan University (CN)
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s13020-024-01050-5
- Citations
- 3
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities