Lyve1‐Driven Nras<sup>Q61R</sup> Causes Edema, Enlarged Lymphatic Vessels, and Hepatic Vascular Defects in Embryonic Mice
Conditional expression of Nras<sup>Q61R</sup> in Lyve1-positive cells caused edema, abnormal lymphatic development, and hepatic vascular defects in mouse embryos. These findings further support the role of NRAS<sup>Q61R</sup> as a driver of the lymphatic overgrowth, vessel enlargement, and dysfunction in the pathophysiology of KLA.
Authors
- Timothy D. Le Cras (ORCID: https://orcid.org/0000-0001-8538-2703)
- C. Griffin McDaniel (ORCID: https://orcid.org/0000-0002-0573-0956)
- Stacey S. Huppert (ORCID: https://orcid.org/0000-0003-3977-8728)
- Patricia Pastura
- Sara Alharbi (ORCID: https://orcid.org/0000-0002-4477-9592)
- Dermot Fox
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1002/pbc.31492
- Citations
- 2
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Cincinnati Children's Hospital Medical Center
- National Institutes of Health