Plasma Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers of Cognitive Decline in People With Human Immunodeficiency Virus
NfL and GFAP were associated with worse cognition cross-sectionally; only NfL was associated with cognitive decline. Their clinical utility remains uncertain given small effect sizes and should be studied in populations with more rapid decline.
Authors
- Petra Bachanová (ORCID: https://orcid.org/0000-0002-9460-4109)
- Robert A. Parker (ORCID: https://orcid.org/0000-0002-9666-5941)
- Albert M. Anderson (ORCID: https://orcid.org/0000-0002-7216-9791)
- Raha Maryam Dastgheyb (ORCID: https://orcid.org/0000-0002-4992-711X)
- Leah H. Rubin (ORCID: https://orcid.org/0000-0003-2749-6328)
- Felicia C. Chow (ORCID: https://orcid.org/0000-0001-9440-9349)
- Emily P. Hyle (ORCID: https://orcid.org/0000-0001-8721-106X)
- Shibani S. Mukerji (ORCID: https://orcid.org/0000-0002-5677-6954)
- Pia Kivisäkk (ORCID: https://orcid.org/0000-0001-9708-7509)
- L. Rosen (ORCID: https://orcid.org/0000-0002-0594-4516)
- Rommi D. Kashlan
- Kunling Wu
- Katherine Tassiopoulos (ORCID: https://orcid.org/0000-0003-4773-2535)
Institutions
- Harvard University (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, San Francisco (US)
- Johns Hopkins Medicine (US)
- Lemuel Shattuck Hospital (US)
- Massachusetts General Hospital (US)
- Cancer Research And Biostatistics (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1093/infdis/jiae623
- Citations
- 4
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Norges Idrettshøgskole
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Cancer Institute
- National Institute of Nursing Research
- National Institute of Allergy and Infectious Diseases
- Fogarty International Center
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Dental and Craniofacial Research
- Office of AIDS Research
- National Institute on Minority Health and Health Disparities
- Eunice Kennedy Shriver National Institute of Child Health and Human Development