Immunogenicity, Reactogenicity, and Safety of a Pentavalent Meningococcal ABCWY Vaccine in Adolescents and Young Adults Who Had Previously Received a Meningococcal ACWY Vaccine: A Phase 3, Randomized Controlled Clinical Study
Immune responses against serogroups ACWY following 1 and 2 doses of investigational MenABCWY vaccine are noninferior to those following MenACWY-CRM in MenACWY-primed adolescents and young adults. Robust immune responses were observed against MenB indicator strains after 2 MenABCWY doses administered 6 months apart. Clinical Trials Registration. NCT04707391.
Authors
- Thembile Mzolo (ORCID: https://orcid.org/0000-0002-9453-6302)
- Paul Matherne
- Ezekiel Fink (ORCID: https://orcid.org/0000-0002-4393-6293)
- Jennifer Gilsoul
- Peter Silas (ORCID: https://orcid.org/0000-0003-0980-0701)
- Mercedes Deluca
- Ana Ceballos (ORCID: https://orcid.org/0000-0003-4564-7361)
- Ricardo Teijeiro
- Daniela Toneatto (ORCID: https://orcid.org/0000-0002-7661-4370)
- Divya Batra
- José Bordón (ORCID: https://orcid.org/0000-0003-4705-6901)
- Peter Richmond (ORCID: https://orcid.org/0000-0001-5796-735X)
- Matthew Hong (ORCID: https://orcid.org/0000-0002-0727-2848)
- Alejandro Hoberman (ORCID: https://orcid.org/0000-0001-6793-8798)
- Peter Richmond (ORCID: https://orcid.org/0000-0001-7562-7228)
- Mark Bloch (ORCID: https://orcid.org/0000-0002-1143-5013)
- Adriana Soto (ORCID: https://orcid.org/0000-0002-4033-2910)
- Andrew Bartlett
- Terry M. Nolan (ORCID: https://orcid.org/0000-0001-6018-3863)
- Elizabeth Gunner
- Maria Lattanzi (ORCID: https://orcid.org/0000-0002-3457-426X)
- William Byars
- Clifford Yut
- Walter Rok
- Ushma Wadia (ORCID: https://orcid.org/0000-0002-8097-5072)
- Julie Kasarjian
- Fernando Riera (ORCID: https://orcid.org/0000-0002-0618-1899)
- Louis Saravolatz
- Joseph B. Domachowske (ORCID: https://orcid.org/0000-0003-1510-1309)
- Rand Farjo
- Ferdinandus de Looze (ORCID: https://orcid.org/0000-0001-7825-4519)
- Garry Wallace
- Chiranjiwi Bhusal (ORCID: https://orcid.org/0000-0002-6650-0142)
- Madhavi Ampajwala
- Katherine J. Sullivan (ORCID: https://orcid.org/0000-0003-2836-0107)
- Douglas L. Mann (ORCID: https://orcid.org/0000-0002-2516-0145)
- Ángela Gentile (ORCID: https://orcid.org/0000-0002-1072-7700)
- Conrado J. Llapur
- Joseph Surber
- Florence Tiong
- Anil Kumar Gupta (ORCID: https://orcid.org/0000-0002-7524-3635)
- Jeremy Peter James Carr
- Adebayo Akinsola
- Gonzalo Pérez Marc
- Mark Arya
- Olga Voloshyna
- Mora Obed
- Gretchen Mitchell
Institutions
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- The Kids Research Institute Australia (AU)
- The University of Western Australia (AU)
- SUNY Upstate Medical University (US)
- Princess Margaret Hospital for Children (AU)
- Coffs Harbour City Council (AU)
- University of Texas Health Science Center at Dallas (US)
- GlaxoSmithKline (India) (IN)
- Peter Doherty Institute (AU)
- Children's Hospital of Pittsburgh (US)
- GGD Amsterdam (NL)
- Murdoch Children's Research Institute (AU)
- Hospital del Niño (PA)
- Hospital General de Niños Ricardo Gutierrez (AR)
- University of Guelph (CA)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1093/cid/ciae622
- Citations
- 3
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- Pfizer
- AstraZeneca
- Sanofi
- Novavax
- Moderna
- Shionogi
- Seqirus