pH-sensitive liposomal curcumin with good biocompatibility for improving therapeutic efficacy by decreasing DNA methylation level in tumor cells
Abstract A new type of pH-sensitive liposome nanoparticles encapsulated with curcumin and doxorubicin was prepared and exhibited high specificity for tumor cells. The liposomal curcumin enables the endosome escape and decrease of the genomic methylation level and DNA methyltransferases expression in A549 and K562 cells for improving therapeutic efficacy.
Authors
- Bingqian Liu (ORCID: https://orcid.org/0000-0001-5710-7210)
- Hong Ma (ORCID: https://orcid.org/0000-0003-3419-4627)
- Weirenbo Wang
- Danping Chen (ORCID: https://orcid.org/0009-0001-9851-037X)
- Chengpeng Li (ORCID: https://orcid.org/0000-0001-6751-2770)
- Zhenchao Wang (ORCID: https://orcid.org/0000-0002-9560-7627)
- Chunmei Gong
- Di Yang
- Mingzheng Shao
- Yanqiong Liu
Institutions
- Guizhou University (CN)
- Guizhou Magic Pharmaceutical (China) (CN)
Publication Details
- Journal
- Chemistry Letters
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1093/chemle/upae243
- Citations
- 1
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.17