The relationship of quantitative indicators sCD56 and sCD16 with the level of immunocompetent cells, cytokines, circulating immune complexes and cyclic nucleotides in practically healthy people living in the Arctic territory

We studied the content of immunocompetent blood cells, phagocytic activity of neutrophils, concentrations of cytokines, circulating immune complexes and levels of cyclic nucleotides (cAMP and cGMP) of serum with different levels of soluble adhesion molecules NCAM (CD56) and immunoglobulin Fc-receptor III (CD16) in practically healthy people living in the Arctic territory. It was found that the increase in serum concentration of sCD56 and sCD16 in practically healthy adults of working age is associated with an increase in the content of cells with the corresponding membrane receptors. The increase in sCD56 concentration occurs with an increase in the content of NK cells (CD3-CD16+CD56+) and T-NK cells (CD3+CD16+CD56+). The increase in sCD16 level is accompanied by a decrease in the content of circulating in the blood lymphocytes predominantly T-helper cells (CD3+CD4+), cytotoxic T-lymphocytes (CD3+CD8+) and activated T-lymphocytes (CD3+HLADR+). Increased sCD56 concentrations were associated with increases in pro-inflammatory IL-1β, IL-6, TNF-α and anti-inflammatory IL-10. Concentrations of circulating immune complexes increased with increasing sCD16 and sCD56 content. The signal conduction activity increases with increasing content of CD16+ and CD56+ leukocytes of peripheral blood and sCD56+ leukocytes and shedding of these molecules occurs against the background of decreasing concentrations of cAMP and cGMP.