DMSO-promoted α-bromination of α-aryl ketones for the construction of 2-aryl-2-bromo-cycloketones
A DMSO-promoted practical one-step α-bromination reaction of α-aryl ketones with NBS has been developed for the construction of 2-aryl-2-bromo-cycloketones. The desired regioselective α-bromination products were isolated in moderate to good yields, with a maximum tested scale of 15 mmol. Notably, ketamine derivatives could be smoothly synthesized in two steps.
Authors
- Hongshuang Wang (ORCID: https://orcid.org/0009-0001-8797-4822)
- Penghui Li (ORCID: https://orcid.org/0000-0001-7071-6547)
- Xiaohui Wang (ORCID: https://orcid.org/0000-0002-3415-5612)
- Haiyan Zhai
Institutions
- University of Science and Technology of China (CN)
- Shenzhen University (CN)
- Chinese Academy of Sciences (CN)
- Changchun Institute of Applied Chemistry (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1039/d4ob01937g
- Citations
- 1
- Primary Topic
- Vanadium and Halogenation Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.16