A case of fulminant neurogenic pulmonary edema successfully treated with phenoxybenzamine and sildenafil

Neurogenic pulmonary edema (NPE) is a clinical condition that arises from various central nervous system (CNS) insults, including traumatic brain injury, intracranial hemorrhage, status epilepticus, meningitis, and brain tumors [1].It is thought to occur due to a massive sympathetic discharge triggered by CNS insult, which leads to cardiopulmonary dysfunction [2].In severe cases, the mortality rate ranges from 60% to 100% [3].Although NPE was first reported over 100 years ago [4], there are few reports on specific treatment modalities for humans.We describe a case of a patient with a fulminant and prolonged course of NPE who re-