Clinically Significant BRCA1 and BRCA2 Germline Variants in Breast Cancer—A Single-Center Experience
The study revealed that PVs in both BRCA genes have a significant frequency among BC patients in our region, and <i>BRCA1</i> carriers tend to develop more aggressive tumors than carriers of <i>BRCA2</i> PVs and patients with no germline PVs in either of the two genes. These observations could provide new epidemiologic data for this disease in our region and contribute further to the development of national screening strategies.
Authors
- Michael Schenker (ORCID: https://orcid.org/0000-0003-2645-6391)
- Cristian Virgil Lungulescu (ORCID: https://orcid.org/0000-0003-3578-3562)
- Georgiana-Cristiana Camen
- Andra Grigorescu
- Florin Burada (ORCID: https://orcid.org/0000-0002-7132-0904)
- Cecil Sorin Mirea
- I Gavrilă
- Anca M. Barbu (ORCID: https://orcid.org/0009-0004-1300-2600)
- Iancu Emil Pleşea (ORCID: https://orcid.org/0000-0003-2686-3878)
- Ștefania Dorobanțu
- Ana Maria Ahmet
- Ioana Streață
- Anca‐Lelia Riza (ORCID: https://orcid.org/0000-0003-2073-8865)
- Andreea Mituț
Institutions
- University of Medicine and Pharmacy of Craiova (RO)
- University of Craiova (RO)
Publication Details
- Journal
- Cancers
- Published
- 2024-12-26
- DOI
- https://doi.org/10.3390/cancers17010039
- Citations
- 2
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.10