A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [<scp><sup>18</sup>F</scp>]fallypride positron emission tomography

Young social drinkers at high versus low risk for substance use disorders did not exhibit larger mesocorticolimbic BOLD activations to alcohol-related cues and their responses poorly differentiated alcohol from juice. These observations raise the possibility that (i) diminished mesocorticolimbic BOLD differentiations between reward-related cues might be a marker of increased risk for substance use disorders, and (ii) previously reported large BOLD responses to drug-related cues in people with substance use disorders might better identify the disease than pre-existing vulnerability.

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Publication Details

Journal
Alcohol Clinical and Experimental Research
Published
2024-12-26
DOI
https://doi.org/10.1111/acer.15511
Primary Topic
Neurotransmitter Receptor Influence on Behavior
Type
article
Field-Weighted Citation Impact
0.00

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article

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography

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Alcohol Clinical and Experimental Research
Neurotransmitter Receptor Influence on Behavior
article

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography

Natalie Castellanos‐Ryan, Maja Nikolic, Natalia Jaworska, Sylvia M. L. Cox, Mara Brendgen, Alain Dagher, Jean R. Séguin, Marco Leyton, Frank Vitaro, Sophie Parent, Richard E. Tremblay, Sylvana Côté, Michel Boivin
article en

Abstract

Young social drinkers at high versus low risk for substance use disorders did not exhibit larger mesocorticolimbic BOLD activations to alcohol-related cues and their responses poorly differentiated alcohol from juice. These observations raise the possibility that (i) diminished mesocorticolimbic BOLD differentiations between reward-related cues might be a marker of increased risk for substance use disorders, and (ii) previously reported large BOLD responses to drug-related cues in people with substance use disorders might better identify the disease than pre-existing vulnerability.

Alcohol Clinical and Experimental ResearchVol. 49(2)
University College Dublin (IE), Montreal Neurological Institute and Hospital (CA), University of Ottawa (CA), Inserm (FR), Université du Québec à Montréal (CA), National Research Tomsk State University (RU), Centre Hospitalier Universitaire Sainte-Justine (CA), Université Laval (CA), McGill University (CA), Concordia University (CA), Université de Montréal (CA)
Fonds de Recherche du Québec-Société et Culture, Canadian Institutes of Health Research, Social Sciences and Humanities Research Council of Canada, Fonds de Recherche du Québec - Santé
Good health and well-being
Openalex Percentile: Top 74%
Neurotransmitter Receptor Influence on Behavior
DOIOpen Access PDFOpenAlex
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