Platelet stimulation-regulated expression of ILK and ITGB3 contributes to intrahepatic cholangiocarcinoma progression through FAK/PI3K/AKT pathway activation
Our data revealed that platelet-related indices were abnormally ascendant in iCCA patients compared to healthy adults. Co-culturing with platelets enhanced the progression of EMT, and the motility and viability of iCCA cells in vitro and in vivo. Proteomic profiling discovered that platelets promoted the development of iCCA through FAK/PI3K/AKT pathway by means of elevating the expression of ILK and ITGB3, indicating that both proteins are promising therapeutic targets for iCCA with the guidance of platelet-related indices.
Authors
- Kai Zhao (ORCID: https://orcid.org/0000-0002-2774-6326)
- Xiangyu Li (ORCID: https://orcid.org/0000-0001-6477-8354)
- Wei Yao (ORCID: https://orcid.org/0000-0002-5728-1304)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1007/s00018-024-05526-3
- Citations
- 6
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- National Natural Science Foundation of China