The Transcriptional Profile of Iron Deficiency in Patients with Heart Failure: Heme-Sparing and Reduced Immune Processes
Iron deficiency is associated with the preservation of heme-related processes at the cost of iron-sulfur clusters. Immune processes are downregulated, uncovering another high energy demand system affected. SIAH2 and CLIC4 might be modifiable factors in the relation between ID and impaired prognosis.
Authors
- Mintu Nath (ORCID: https://orcid.org/0000-0002-0753-0464)
- John G.F. Cleland (ORCID: https://orcid.org/0000-0002-1471-7016)
- Ridha I.S. Alnuwaysir (ORCID: https://orcid.org/0000-0001-7012-9422)
- Mark M. Iles (ORCID: https://orcid.org/0000-0002-2603-6509)
- Martijn F. Hoes (ORCID: https://orcid.org/0000-0002-0234-438X)
- George Markousis‐Mavrogenis (ORCID: https://orcid.org/0000-0001-8192-6670)
- Niels Grote Beverborg (ORCID: https://orcid.org/0000-0003-4629-9960)
- Marco Metra (ORCID: https://orcid.org/0000-0001-6691-8568)
- Haye H. van der Wal
- Chim C. Lang (ORCID: https://orcid.org/0000-0002-4530-3078)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Simon P.R. Romaine (ORCID: https://orcid.org/0000-0003-4732-7572)
- Leong L. Ng (ORCID: https://orcid.org/0000-0002-6553-5749)
- Peter van Meer (ORCID: https://orcid.org/0000-0001-6493-1697)
- Stefan D. Anker (ORCID: https://orcid.org/0000-0003-3331-7314)
- Dirk J. van Veldhuisen
- Kenneth Dickstein
- Andrea Koekoemoer
Institutions
- University Medical Center Groningen (NL)
- University of Leicester (GB)
- University of Groningen (NL)
- Stavanger University Hospital (NO)
- Maastricht University Medical Centre (NL)
- Glenfield Hospital (GB)
- Ninewells Hospital (GB)
- Maastricht University (NL)
- Lung Institute (US)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- German Centre for Cardiovascular Research (DE)
- Deutsches Herzzentrum München (DE)
- The Robertson Trust (GB)
- Berlin Heart (Germany) (DE)
- NIHR Leicester Biomedical Research Centre (GB)
- University of Bergen (NO)
- Imperial College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- University of Brescia (IT)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1002/ejhf.3562
- Citations
- 2
- Primary Topic
- Erythropoietin and Anemia Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- European Commission
- Horizon 2020 Framework Programme
- Medical Research Council