Three Case Reports of Melanocytomas: A Melanoma to be or not to be?

More recently, clinically-appearing atypical blue nevi which have been biopsied have been read by dermatopathologists as melanocytomas. We have noticed this phenomenon over the last 1-2 years. The spectrum between blue nevi, atypical blue nevi and melanocytomas seems to be blurry. With the advent of newer immunohistochemistry stains including, but not limited to, PRAME, Mel/Ki-67, p16 and BAP1; there have been more outright calls of melanocytomas. Below we describe three cases which, to us as clinicians, are an enigma. The proliferation of these immunostains – while it has helped in malignant differentiation – seems to also lead to confusing diagnoses.