Hazard assessment of nanomaterials: how to meet the requirements for (next generation) risk assessment
The study highlights the potential of in silico models to effectively identify biologically active nanoforms based on their physico-chemical properties, reinforcing previous knowledge on the relevance of certain properties, such as aspect ratio. The potential of implementing in vitro methods into NGRA is underlined, cross-validating three cytotoxicity assessment methods, and showcasing their strength in terms of sensitivity and suitability for the testing of NMs.
Authors
- Sergey Shaposhnikov (ORCID: https://orcid.org/0000-0002-3957-703X)
- Eleonora Longhin (ORCID: https://orcid.org/0000-0002-3939-7135)
- Agnieszka Gajewicz (ORCID: https://orcid.org/0000-0001-7702-210X)
- Espen Mariussen (ORCID: https://orcid.org/0000-0001-5150-942X)
- Elise Rundén‐Pran (ORCID: https://orcid.org/0000-0002-5541-4513)
- Neus G. Bastús (ORCID: https://orcid.org/0000-0002-3144-7986)
- Víctor Puntes (ORCID: https://orcid.org/0000-0001-8996-9499)
- Mária Dušinská (ORCID: https://orcid.org/0000-0003-1358-1652)
- Mihaela Roxana Cimpan (ORCID: https://orcid.org/0000-0003-2029-3173)
- Iván Ríos-Mondragón (ORCID: https://orcid.org/0000-0001-6819-0718)
- Congying Zheng (ORCID: https://orcid.org/0000-0002-6758-0930)
- Martí Busquets
- Ole-Bendik Hofshagen
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Health Effects Institute (US)
- Norwegian Institute of Public Health (NO)
- University of Gdańsk (PL)
- Institut Català de Nanociència i Nanotecnologia (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Oslo Cancer Cluster (NO)
- University of Bergen (NO)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12989-024-00615-4
- Citations
- 12
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Norges Forskningsråd
- Horizon 2020 Framework Programme
- H2020 Industrial Leadership
- H2020 Spreading Excellence and Widening Participation