SARS-CoV-2 membrane protein induces neurodegeneration via affecting Golgi-mitochondria interaction
M disturbs the distribution and function of Golgi, leading to mitochondrial abnormality and eventually neurodegeneration via a PI4KIIIβ-mediated mechanism. This study reveals a potential mechanism for COVID-19 neurological symptoms and opens a new avenue for development of therapeutic strategies targeting SARS-CoV-2 M or mitochondria.
Authors
- Yanni Peng (ORCID: https://orcid.org/0000-0002-5850-8996)
- Caifang Wang
- Hailong Han
- Zhuohua Zhang (ORCID: https://orcid.org/0000-0002-1394-0697)
- Yaohui He (ORCID: https://orcid.org/0000-0002-8235-8924)
- Hualan Chen (ORCID: https://orcid.org/0000-0001-8910-898X)
- Yikang S. Rong (ORCID: https://orcid.org/0000-0002-9787-9669)
- Danling Wang (ORCID: https://orcid.org/0000-0003-0119-441X)
- Wen Liu (ORCID: https://orcid.org/0000-0003-3434-4162)
- Ye Chen (ORCID: https://orcid.org/0000-0003-3671-2504)
- Fang Li (ORCID: https://orcid.org/0000-0003-0352-9703)
- Jingfei Wang
- Zhouyang Deng
- Fang Wang (ORCID: https://orcid.org/0000-0002-8808-8531)
Institutions
- Central South University (CN)
- Xiamen University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Hengyang Academy of Agricultural Sciences (CN)
- Xiangya Hospital Central South University (CN)
- Harbin Veterinary Research Institute (CN)
- University of South China (CN)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s40035-024-00458-1
- Citations
- 8
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 2.95
Funders
- National Natural Science Foundation of China
- Hunan Provincial Science and Technology Department
- China Postdoctoral Science Foundation