N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson’s disease
These findings underscore the necessity of utilising a multiplex approach to detect α-Syn, most importantly including the N-terminus, to capture the entire spectrum of α-Syn proteoforms in α-synucleinopathies. The data provide novel insights toward the biological differentiation of these α-synucleinopathies and pave the way for more refined antemortem diagnostic methods to facilitate early identification and intervention of these neurodegenerative diseases.
Authors
- Birger Victor Dieriks (ORCID: https://orcid.org/0000-0002-9392-3327)
- James A. Wiseman (ORCID: https://orcid.org/0000-0001-9880-1612)
- Maurice A. Curtis (ORCID: https://orcid.org/0000-0003-4496-0233)
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Clinton P. Turner (ORCID: https://orcid.org/0000-0002-2138-7633)
- Richard L. M. Faull (ORCID: https://orcid.org/0000-0003-3385-9498)
- YuHong Fu
Institutions
- The University of Sydney (AU)
- University of Auckland (NZ)
- UNSW Sydney (AU)
- Brain Research New Zealand (NZ)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s40035-024-00456-3
- Citations
- 10
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.69
Funders
- Neuroscience Research Australia