Delivery of mRNA Vaccine and its Application for COVID-19

mRNA vaccine has potential to bring a revolutionary change to conventional vaccines due to its high efficacy, minimal risk profile, less time needed for development, and potential to be manufactured substantially. This innovation comes to spotlight as it successfully demonstrated its capacity to treat severe pandemic like COVID-19. Over decades of research on mRNA vaccine, a crucial focus has been the efficient delivery of mRNA vaccines into the cytosol to facilitate protein synthesis, and thus several different methods of mRNA delivery have been developed. This passage reviews ways of mRNA delivery, especially lipid-based nanoparticle (LNP) and its application in treating COVID-19.