A Practical Guide for Diagnostic Investigations and Special Considerations in Patients With Huntington’s Disease in Korea
This review provides a comprehensive framework for the diagnostic approach and management of Huntington's disease (HD) tailored to the Korean population. Key topics include genetic counseling, predictive testing, and reproductive options like preimplantation genetic testing. Strategies for assessing disease progression in premanifest HD through laboratory investigations, biofluid, and imaging biomarkers are highlighted. Special considerations for juvenile and late-onset HD, along with associated comorbidities like diabetes mellitus, hypertension, and cardiovascular abnormalities, are discussed. The guide emphasizes personalized symptom management, including pharmacotherapy, physical therapy, and nutritional support, while exploring emerging disease-modifying treatments. A multidisciplinary care model is advocated to improve outcomes for HD patients and caregivers in Korea.
Authors
- Manho Kim (ORCID: https://orcid.org/0000-0002-0277-6326)
- Dallah Yoo (ORCID: https://orcid.org/0000-0002-9736-6118)
- Jangsup Moon (ORCID: https://orcid.org/0000-0003-1282-4528)
- Eungseok Oh (ORCID: https://orcid.org/0000-0003-2068-3235)
- Seong‐Beom Koh (ORCID: https://orcid.org/0000-0002-9411-4863)
- Chaewon Shin (ORCID: https://orcid.org/0000-0002-4157-492X)
- Ryul Kim (ORCID: https://orcid.org/0000-0002-8754-9180)
- Jong‐Min Kim (ORCID: https://orcid.org/0000-0001-5723-3997)
- Jee‐Young Lee (ORCID: https://orcid.org/0000-0002-9120-2075)
- Minkyeong Kim (ORCID: https://orcid.org/0000-0001-8376-867X)
- Beomseok Jeon
Institutions
- Seoul National University (KR)
- Chungnam National University (KR)
- Korea University Medical Center (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- Kyung Hee University (KR)
- Gyeongsang National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Chungnam National University Hospital (KR)
Publication Details
- Journal
- Journal of Movement Disorders
- Published
- 2024-12-27
- DOI
- https://doi.org/10.14802/jmd.24232
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chungnam National University
- Seoul National University
- National Health Insurance Service