Protective Effects of Tea Polyphenols on Alcoholic Liver-injured Mice and Alcoholic Stomach-injured Mice

The aim of this review is to investigate the protective effects of tea polyphenols on alcoholic liver injury and gastric injury and their potential mechanisms. Alcoholic liver injury and gastric injury are serious health problems caused by chronic excessive alcohol consumption, involving complex pathological mechanisms such as oxidative stress, inflammatory responses, abnormalities in immune regulation, apoptosis, disorders of lipid metabolism and fibrosis. Tea polyphenols, a class of polyphenolic compounds derived from tea, have been shown in several studies to have significant protective effects against these impairments due to their potent antioxidant and anti-inflammatory properties. This paper presents a comprehensive analysis of existing studies on tea polyphenols in the treatment of alcoholic liver injury and gastric injury, including their mechanisms of action such as antioxidant, anti-inflammatory, modulation of lipid metabolism, promotion of tissue repair, protection of the mucosal barrier, and modulation of intestinal flora. Despite the potential for clinical applications of tea polyphenols, current studies have limitations, including low bioavailability and stability issues. Future research should focus on improving the stability and bioavailability of tea polyphenols, conducting clinical studies to validate their safety and efficacy, and exploring the use of tea polyphenols in combination with other therapeutic agents. This paper provides a scientific basis for the use of tea polyphenols in the prevention and treatment of alcoholic liver injury and gastric injury and points out directions for future research.