Intranasal Immunization with DNA Vaccine HA-CCL19/Polyethylenimine/Chitosan Composite Provides Immune Protection Against H7N9 Infection
CCL19 conspicuously augments the immunogenicity of the influenza virus HA DNA and conserves the integrity of the vaccine antigen. Simultaneously, CS and PEI proficiently facilitate the mucosal delivery of DNA, thereby eliciting mucosal immunity related to DNA vaccines. This study investigated the feasibility of utilizing nasal mucosa for DNA vaccine immunization, which holds significant implications for the advancement and application of DNA vaccines in public health.
Authors
- Yizhen Xiang (ORCID: https://orcid.org/0009-0001-3190-1384)
- Hongbo Zhang (ORCID: https://orcid.org/0000-0003-2584-7139)
- Ze Chen (ORCID: https://orcid.org/0000-0001-8236-5764)
- Youcai An (ORCID: https://orcid.org/0009-0008-4507-1538)
Institutions
- Hunan Normal University (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2024-12-26
- DOI
- https://doi.org/10.3390/vaccines13010010
- Citations
- 3
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.72