Predicting benefit from PARP inhibitors using deep learning on H&E-stained ovarian cancer slides
Together, our results indicate that it might be possible to generate a predictor of benefit from PARP inhibitors based on the DL-mediated analysis of WSIs. However, further studies with larger cohorts and further methodological improvements will be necessary to generate a predictor with clinically useful accuracy across independent patient cohorts.
Authors
- Timo Gaiser (ORCID: https://orcid.org/0000-0002-6022-073X)
- Stefan Fröhling (ORCID: https://orcid.org/0000-0001-7907-4595)
- Frederik Marmé (ORCID: https://orcid.org/0000-0002-6591-3367)
- Tobias Brodkorb
- Florian Heitz (ORCID: https://orcid.org/0000-0002-2412-0352)
- C. Zamagni (ORCID: https://orcid.org/0000-0002-7143-9091)
- Philip C. Schouten (ORCID: https://orcid.org/0000-0002-0822-7133)
- Mohamad Kayali (ORCID: https://orcid.org/0000-0003-2092-5695)
- Katharina Prieske (ORCID: https://orcid.org/0000-0002-4245-6503)
- Antonio González‐Martín (ORCID: https://orcid.org/0000-0003-0276-0778)
- Lennard Kiehl (ORCID: https://orcid.org/0000-0002-6967-7568)
- Christoph Wies (ORCID: https://orcid.org/0000-0001-7136-298X)
- Jan Hauke (ORCID: https://orcid.org/0000-0001-8236-4075)
- Éric Pujade-Lauraine (ORCID: https://orcid.org/0000-0002-0759-7263)
- Isabelle Laure Ray-Coquard (ORCID: https://orcid.org/0000-0003-2472-8306)
- Isabelle Treilleux (ORCID: https://orcid.org/0000-0003-3919-5506)
- Titus Josef Brinker (ORCID: https://orcid.org/0000-0002-3620-5919)
- Eva Krieghoff‐Henning (ORCID: https://orcid.org/0000-0001-8381-3100)
- Philipp Harter
- Eric Hahnen
- Stefan Kommoss
Institutions
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Integrated Oncology (United States) (US)
- Centre Léon Bérard (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- National Center for Tumor Diseases (DE)
- Azienda USL di Bologna (IT)
- University Children's Hospital Tübingen (DE)
- Arcagy Gineco (FR)
- Clinica Universidad de Navarra (ES)
- Kliniken Essen-Mitte (DE)
- University Hospital Cologne (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1016/j.ejca.2024.115199
- Citations
- 5
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.41