Combination of bacteriophage and antibiotic therapy to control antimicrobial drug resistance bacterial infections: the evolutionary trade-off mechanism

Antimicrobial resistance (AMR) is a global health threat because of the emergence of infections with multidrug-resistant (MDR) bacterial strains. Combination therapy, involving both phages and antibiotics, is being explored to approach this burden. This combination therapy offers a promising solution by overcoming resistance, enhancing treatment efficacy, and serving as an alternative to combat bacterial infections. However, challenges like phage resistance and the need for extensive clinical trials must be addressed. Nevertheless, the synergistic action of phages in combination with antibiotics, provides hope in effectively combating AMR and safeguarding public health. Understanding the evolutionary trade-off and optimizing this approach, researchers aim to pave the way for more successful treatments in the future.