REVIEW OF CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC METHODS FOR DAPAGLIFLOZIN ESTIMATION IN BULK AND FORMULATIONS

Dapagliflozin, inhibitor, is widely used in the management of type 2 diabetes mellitus due to its ability to promote glucose excretion via urine.The accurate estimation of dapagliflozin, both as a single drug and in combination with other antidiabetic agents, is essential for ensuring drug quality, efficacy, and regulatory compliance.Various analytical techniques, such as UV spectrophotometry, High-Performance Liquid Chromatography (HPLC), and High-Performance Thin-Layer Chromatography (HPTLC), have been employed for its quantification in bulk drugs and pharmaceutical formulations.UV spectrophotometry offers a simple, cost-effective, and rapid method for routine estimation, especially in single-component formulations.HPLC, on the other hand, provides high sensitivity, precision, and the ability to separate dapagliflozin from impurities or other co-administered drugs in complex matrices, making it the method of choice for stability studies and quality control.HPTLC offers a flexible and efficient technique for high-throughput analysis, allowing the simultaneous quantification of multiple drugs in combination formulations.This review highlights the development, validation, and comparative analysis of these techniques, focusing on their respective advantages, limitations, and applicability for the accurate quantification of dapagliflozin in pharmaceutical and biological samples.