Investigating the inflammatory mechanism of notoginsenoside R1 in Diabetic nephropathy via ITGB8 based on network pharmacology and experimental validation
We identified several NGR1 pharmacological targets and found that the ITGB8 protein is a key drug target linked to inflammation and DN. ITGB8 is critical for DN development and can help to reduce high blood sugar-induced podocyte inflammation.
Authors
- ChangYan Li (ORCID: https://orcid.org/0000-0003-2565-7220)
- Jingyuan Ma
- Jiangming Wang
- Liang Zhang (ORCID: https://orcid.org/0000-0003-0782-0688)
- Geng Chen (ORCID: https://orcid.org/0000-0002-2320-2161)
- WenXing Fan (ORCID: https://orcid.org/0000-0002-1381-3073)
- Luyao Shi (ORCID: https://orcid.org/0000-0003-1771-5179)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s10020-024-01055-8
- Citations
- 7
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- National Natural Science Foundation of China
- Kunming Medical University