Antimicrobial resistance profile of Pseudomonas aeruginosa strains

Antimicrobial resistance is one of the most serious threats facing humanity today. Th e majority of pathogens on the WHO list with high resistance to antibiotics are Gram-negative bacteria, including Pseudomonas. Data on the etiological structure of septico-purulent infections (SPIs), multiple antibiotic resistance of microorganisms isolated from patients hospitalized at the Institute of Emergency Medicine were analyzed. Gram-positive bacteria accounted for 40,15% among the isolated strains, with a predominance of Enterococcus faecalis, Staphylococcus aureus and Staphylococcus epidermidis species. Gram-negative bacteria constituted 56,34%, the most prevalent being Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli. P. aeruginosa had the highest rate of MDR – 92,71%, followed by Acinetobacter spp. followed by Acinetobacter spp., E. faecium and K. pneumoniae. XDR prevalence was highest in P. aeruginosa (81,50%), Acinetobacter spp., K. pneumoniae and E. faecium. PDR rates were high in strains of K. pneumoniae, E. faecium, P. aeruginosa and Acinetobacter spp. P. aeruginosa showed increased resistance to penicillin’s, beta-lactams with inhibitors and third/ fourth generation cephalosporins. Extremely high resistance was also observed to Imipenem, Meropenem and fluoroquinolone. Moderate resistance was observed to aminoglycosides, while sensitivity was high to Colistin and Polymyxin B. P. aeruginosa strains from intensive care and reanimation (ICU) wards showed very high resistance to various antibiotics. Isolates from septic surgery and trauma wards also showed increased antibiotic resistance.