Clostridioides difficile Infection: A Continuing Challenge in Public Health

This study focuses on the analysis of a sample of 134 patients admitted to IMSP SCBI „Toma Ciorbă” with a diagnosis of enterocolitis caused by Clostridioides difficile during the period from March 2020 to April 2024. The research aimed to evaluate the clinical, epidemiological, and laboratory aspects of CDI cases that occurred during the COVID-19 pandemic as well as the long COVID period. The following research methods were applied: documentary and mathematical. A significant increase in the incidence of CDI in the Republic of Moldova during the COVID-19 pandemic, as well as in cases of recurrent Clostridioides difficile, was observed compared to the pre-pandemic period. The imbalance of the intestinal microbiota, resulting from prolonged antibiotic therapy, promotes colonization with C. difficile as well as other types of pathogenic flora.