Evaluation of the interaction of some compounds against pathogenicity factors of staphylococcus aureus

Suppression of the pathogenicity factors of Staphylococcus aureus strains by means of medicines reduces their infectious potential. Th e purpose of the research is to test some coordinating compounds and extracts from Spirulina platensis to evaluate their interaction against some pathogenicity factors of Staphylococcus aureus. In the present study, the antibiofilm and antilysozyme activity of three newly synthesized chemical compounds and three extracts from Spirulina platensis was experimentally tested. A greater degree of inhibition of microbial biofilms as well as antilysozyme activity was demonstrated by the combinations of biological and chemical compounds compared to the activity of these taken separately. More active or proven to be combinations of biological extracts and chemical compounds in concentrations of 50% and 75%. Th e study provides a potential therapeutic option for antimicrobialresistant S. aureus bacteria by combining biological extracts and chemical compounds from different classes. Th e obtained results are promising and can be used for the development of future therapeutic strategies.