Consensus Based Indian Guidelines for the Management of Pemphigus Vulgaris and Pemphigus Foliaceous

Pemphigus is an autoimmune blistering disorder characterized by the presence of intraepidermal blisters and erosions, primarily affecting the mucosa and/or skin. There are no established Indian guidelines for the management of pemphigus, and Western guidelines cannot be directly applied due to differences in clinicodemographic profiles, comorbidities, and resource limitations. These guidelines aim to provide Indian dermatologists with evidence-based and consensus-driven recommendations for the management of pemphigus vulgaris (PV) and pemphigus foliaceous (PF), taking into account the unique challenges posed by the Indian healthcare setting. The guidelines focus on the comprehensive management of PV and PF, addressing diagnosis, treatment, monitoring, and follow-up. It is intended for dermatologists working in both outpatient and inpatient settings across India. The first draft of the guidelines was prepared by the writing group and then reviewed by 19 national experts in pemphigus management, including inputs from allied specialties. Areas with limited evidence or anticipated variation in recommendations were subjected to rounds of voting, with responses categorized as "strongly agree," "agree," "neutral," "disagree," or "strongly disagree." Suggestions were incorporated, and statements were revised until a mean agreement score of 4 or higher was reached across 16 key areas after four voting rounds. These guidelines offer a structured approach to managing pemphigus in India, addressing the need for region-specific recommendations that account for unique challenges such as resource constraints and specific comorbidities in Indian patients. They serve as a valuable resource for dermatologists treating pemphigus in a range of clinical settings.

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Publication Details

Journal
Indian Dermatology Online Journal
Published
2024-12-26
DOI
https://doi.org/10.4103/idoj.idoj_1059_24
Citations
5
Primary Topic
Autoimmune Bullous Skin Diseases
Type
article
Field-Weighted Citation Impact
2.12
Controls
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article

Consensus Based Indian Guidelines for the Management of Pemphigus Vulgaris and Pemphigus Foliaceous

Ashutosh Nath Aggrawal, Soham Mukherjee, Keshavamurthy Vinay, Vishal Gupta et al.
5 citations
Indian Dermatology Online Journal
Autoimmune Bullous Skin Diseases
2.12
article

Consensus Based Indian Guidelines for the Management of Pemphigus Vulgaris and Pemphigus Foliaceous

Ashutosh Nath Aggrawal, Soham Mukherjee, Keshavamurthy Vinay, Vishal Gupta, Kidangazhiathmana Ajithkumar, Rahul Mahajan, Shekhar Neema, Shyamanta Barua, Shikha Shah, Manas Chatterjee, Arka De, Sheetanshu Kumar, Vishal Thakur, Raghavendra Rao, Reena Rai, Shankar Prinja, Murlidhar Rajagopalan, Hitaishi Mehta, Laxmisha Chandrashekar, Deepika Pandhi, Shital Poojary, Geeti Khullar, Archana Singal, Sanjeev Handa, Sujay Khandpur, Bela J. Shah, Seetharam Anjaneyulu Kolalapudi, Dipankar De
article en
5 citations

Abstract

Pemphigus is an autoimmune blistering disorder characterized by the presence of intraepidermal blisters and erosions, primarily affecting the mucosa and/or skin. There are no established Indian guidelines for the management of pemphigus, and Western guidelines cannot be directly applied due to differences in clinicodemographic profiles, comorbidities, and resource limitations. These guidelines aim to provide Indian dermatologists with evidence-based and consensus-driven recommendations for the management of pemphigus vulgaris (PV) and pemphigus foliaceous (PF), taking into account the unique challenges posed by the Indian healthcare setting. The guidelines focus on the comprehensive management of PV and PF, addressing diagnosis, treatment, monitoring, and follow-up. It is intended for dermatologists working in both outpatient and inpatient settings across India. The first draft of the guidelines was prepared by the writing group and then reviewed by 19 national experts in pemphigus management, including inputs from allied specialties. Areas with limited evidence or anticipated variation in recommendations were subjected to rounds of voting, with responses categorized as "strongly agree," "agree," "neutral," "disagree," or "strongly disagree." Suggestions were incorporated, and statements were revised until a mean agreement score of 4 or higher was reached across 16 key areas after four voting rounds. These guidelines offer a structured approach to managing pemphigus in India, addressing the need for region-specific recommendations that account for unique challenges such as resource constraints and specific comorbidities in Indian patients. They serve as a valuable resource for dermatologists treating pemphigus in a range of clinical settings.

Indian Dermatology Online JournalVol. 16(1)
Lady Hardinge Medical College (IN), Apollo Hospitals (IN), University College of Medical Sciences (IN), PSG Institute of Medical Sciences & Research (IN), Government Medical College (IN), GSL Medical College & General Hospital (IN), Post Graduate Institute of Medical Education and Research (IN), K J Somaiya Medical College (IN), Jawaharlal Institute of Post Graduate Medical Education and Research (IN), All India Institute of Medical Sciences (IN), B.J. Medical College (IN), Kasturba Medical College, Manipal (IN), Assam Medical College (IN)
Openalex Percentile: Top 12%
Autoimmune Bullous Skin Diseases
2.12
DOIOpen Access PDFOpenAlex
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