Idiopathic pulmonary hemosiderosis: challenges of differential diagnosis
Idiopathic pulmonary hemosiderosis (IPH) is a rare disease of unclear etiology that belongs to interstitial lung diseases and is characterized by a triad of symptoms: hemoptysis, iron deficiency anemia, and diffuse interstitial changes on computed tomography (CT) of the chest cavity. IPH can occur at any age, but the disease develops in childhood in 80% of cases, more often before 10 years of age. A significant proportion of pulmonary hemosiderosis cases in this age group remain undiagnosed. The purpose of the study is to demonstrate a clinical case illustrating the features of differential diagnosis and therapy of IPH during the COVID-19 pandemic. Conclusion. An 8-year-old girl was diagnosed with IPH based on fever, shortness of breath, weakness, and severe iron-deficient anemia. The chest CT scan revealed diffuse interstitial ground-glass opacity in lungs. The lung biopsy revealed hemosiderin deposits and hemosiderophages in the alveolar lumens. Treatment with systemic glucocorticoids (SGC) and azathioprine was effective. The patient was followed for 3 years.
Authors
- M. F. Dubko (ORCID: https://orcid.org/0000-0002-6834-1413)
- Ольга Федоровна Позднякова (ORCID: https://orcid.org/0000-0001-6977-757X)
- Yu.V. Peshekhonova
- Svetlana I. Petrova (ORCID: https://orcid.org/0000-0003-4212-416X)
- Л. А. Желенина (ORCID: https://orcid.org/0000-0001-8474-5154)
- Elena P. Fedotova (ORCID: https://orcid.org/0000-0002-2975-1014)
- А. А. Кузнецова (ORCID: https://orcid.org/0000-0002-0157-4175)
- O. L. Krasnogorskaya (ORCID: https://orcid.org/0000-0001-6256-0669)
- Yu. B. Klyukhina (ORCID: https://orcid.org/0000-0002-2280-8436)
- Maria V. Kuropatenko (ORCID: https://orcid.org/0000-0003-4214-9412)
- Mikhail Mikhaylovich Kostik (ORCID: https://orcid.org/0000-0002-1180-8086)
- Natalia M. Solomatina (ORCID: https://orcid.org/0009-0006-2779-3479)
- I. I. Grafskaya (ORCID: https://orcid.org/0000-0003-1472-0044)
- A. A. Bukovskaya (ORCID: https://orcid.org/0009-0006-3596-8275)
Institutions
- Institute of Experimental Medicine (RU)
- Saint Petersburg State Pediatric Medical University (RU)
Publication Details
- Journal
- PULMONOLOGIYA
- Published
- 2024-12-26
- DOI
- https://doi.org/10.18093/0869-0189-2024-4444
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00