Mutational signatures define immune and Wnt-associated subtypes of ampullary carcinoma
Immunogenicity and Wnt pathway associations, emphasised by the mutational signatures, defined patients with prospective sensitivity to either immunotherapy or Wnt pathway inhibitors. This emphasises a novel mutational signature-based AMPAC classification with prognostic potential, suggesting prospective implications for subgroup-specific management of patients with AMPAC.
Authors
- Antonio Pea (ORCID: https://orcid.org/0000-0002-0509-6756)
- David K. Chang (ORCID: https://orcid.org/0000-0002-4821-3078)
- Ann W. Hsing (ORCID: https://orcid.org/0000-0003-0756-3511)
- Colm J. O’Rourke (ORCID: https://orcid.org/0000-0002-2224-2663)
- Jesper B. Andersen (ORCID: https://orcid.org/0000-0003-1760-5244)
- Rui Caetano Oliveira (ORCID: https://orcid.org/0000-0002-7202-8059)
- Monika Lewińska (ORCID: https://orcid.org/0000-0002-5275-992X)
- A Taranta (ORCID: https://orcid.org/0000-0001-6478-2185)
- Ekaterina Zhuravleva (ORCID: https://orcid.org/0000-0001-7522-9828)
- Jill Koshiol (ORCID: https://orcid.org/0000-0002-3832-6204)
- Yu-Tang Gao
- Asif Rashid (ORCID: https://orcid.org/0000-0002-2922-8768)
Institutions
- University of Verona (IT)
- University of Copenhagen (DK)
- The University of Texas MD Anderson Cancer Center (US)
- Hospitais da Universidade de Coimbra (PT)
- Shanghai Cancer Institute (CN)
- National Cancer Institute (US)
- University of Glasgow (GB)
- Stanford University (US)
Publication Details
- Journal
- Gut
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1136/gutjnl-2024-333368
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Kræftens Bekæmpelse
- Novo Nordisk