MINERAL COMPONENT OF ORAL FLUID AS AN INDICATOR OF REPARATIVE OSTEOGENESIS AFTER TOOTH EXTRACTION

Tooth extraction is known to results in the formation of a bone defect and the gradual atrophy of the alveolar process, which can negatively impact the outcomes of dental rehabilitation. Adequate alveolar bone volume and the complete morphology of the alveolar process are essential for achieving aesthetic and functional reconstruction. The aim of this study was to determine the effect of cryopreserved placenta and quercetin on the levels of total and ionized calcium in oral fluid during the process of reparative osteogenesis following tooth extraction. Results. The study found that the content of total calcium in the oral fluid of patients showed a statistically significant increase on the 20th day after the tooth extraction procedure: by 5.2%, 3.7%, and 4.8% in the 1st, 2nd, and 3rd clinical groups, respectively. The dynamics of ionized calcium were even more pronounced. On day 20 after tooth extraction, the levels of ionized calcium increased significantly in all three clinical groups: by 23.0%, 9.6%, and 33.3%, respectively. In the second clinical group, the ionized calcium content was lower by 16.7% compared to the control group, and by 12.1% compared to the group where cryopreserved placenta was used alongside the standard treatment protocol, with these differences being statistically significant. Ninety days after tooth extraction, the levels of ionized calcium showed a statistically significant decrease: by 13.2%, 6.3%, and 13.5%, respectively, in the 1st, 2nd, and 3rd clinical groups. The least change in total and ionized calcium levels in the oral fluid was observed in patients treated with the standard protocol supplemented with cryopreserved placenta and quercetin. This may be attributed to local bone tissue resorption in the lower jaw, resulting in the release of this mineral from the bones.