Acute Tubular Injury and Fanconi Syndrome Associated With Red Yeast Rice Supplement
In September 2023, reports from Japan linked the use of red yeast rice supplements (Benikoji CholesteHelp, Kobayashi Pharmaceutical Co., Osaka, Japan) with renal impairment, particularly tubulointerstitial dysfunction. Several individuals who consumed these supplements experienced notable kidney damage, including acute kidney injury (AKI) and Fanconi syndrome, both characterized by tubular dysfunction. Histopathological findings, such as vacuolization, flattening of proximal tubular cells, and mitochondrial swelling, were also observed in these cases.
Authors
- Taihei Suzuki (ORCID: https://orcid.org/0000-0002-9531-7814)
- Kunio Kawanishi (ORCID: https://orcid.org/0000-0003-3502-3467)
- Dedong Kang (ORCID: https://orcid.org/0000-0002-2474-8609)
- Takashi Takaki (ORCID: https://orcid.org/0000-0003-2498-5505)
- Keishu Kawanishi
- Fumihiko Sasai (ORCID: https://orcid.org/0000-0003-0487-0719)
- Kazuho Honda
- Tomoki Morikawa
- Fumihiko Koiwa (ORCID: https://orcid.org/0000-0003-3832-701X)
- Hirokazu Honda (ORCID: https://orcid.org/0000-0002-5634-6145)
- Yuki Kajio
- Masaki Baba
- Mayu Shimokawa
- Mika Shiomi
Institutions
- SHOWA Medical University (JP)
- University of Tsukuba (JP)
- SHOWA Medical University Fujigaoka Hospital (JP)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1016/j.ekir.2024.12.016
- Citations
- 3
- Primary Topic
- Microbial Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Japan Agency for Medical Research and Development