Therapeutic effects of tripterygium glycosides on periodontitis: Exploring the role of ursolic acid and the RIPK3/NLRP3 signaling pathway
This study demonstrated that TGs effectively treat periodontitis by mitigating alveolar bone loss and suppressing inflammation. As the primary component of TGs, UA exerts therapeutic effects by inhibiting the expression of RIPK3, which in turn influences the activation of the NLRP3 inflammasome and the subsequent expression of downstream inflammatory factors. The findings of this study offer a theoretical foundation for the clinical application of TGs in the management of periodontitis.
Authors
- Li Chen (ORCID: https://orcid.org/0000-0002-5138-2606)
- Ying Gao (ORCID: https://orcid.org/0000-0002-7486-6822)
- Lina Yang
- Ren Long
Institutions
- Shanghai Stomatological Hospital (CN)
- Minhang District Central Hospital (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1016/j.intimp.2024.113903
- Citations
- 2
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.43