Deconstructing Delay Discounting in Human Cocaine Addiction Using Computational Modeling and Neuroimaging
We demonstrated that measuring delay discounting and choice sharpness directly with a novel computational model explained impulsive discounting choices in patients with CUD better than standard hyperbolic discounting. Our findings highlight a distinct neuropsychological phenotype of impulsive discounting, which may be generalizable to other patient groups.
Authors
- Salvatore Nigro (ORCID: https://orcid.org/0000-0001-7566-7983)
- Karen D. Ersche (ORCID: https://orcid.org/0000-0002-3203-1878)
- Rudolf N. Cardinal (ORCID: https://orcid.org/0000-0002-8751-5167)
- Elijah Mak (ORCID: https://orcid.org/0000-0002-6437-8024)
- Tsen Vei Lim (ORCID: https://orcid.org/0000-0002-6565-4326)
- Michal M. Graczyk
Institutions
- Universität Hamburg (DE)
- Heidelberg University (DE)
- University of Cambridge (GB)
- Fulbourn Hospital (GB)
- University Hospital Heidelberg (DE)
- Istituto di Nanotecnologia (IT)
- Central Institute of Mental Health (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Cambridgeshire and Peterborough NHS Foundation Trust (GB)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1016/j.bpsc.2024.12.010
- Citations
- 1
- Primary Topic
- Substance Abuse Treatment and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Society for the Study of Addiction
- National Institute for Health and Care Research
- University of Cambridge
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre