Bcl6 controls the stability and suppressive function of regulatory T cells in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common cancer globally. Most studies in HNSCC demonstrated that regulatory T (Treg) cells confine the anti-tumor activity of effector T cells which may contribute to the immune escape and uncontrolled tumor progression. Here, we uncovered that the specific abrogation of Bcl6 in Treg cells resulted in significantly delayed malignant transformation of 4NQO-induced tumorigenesis. Bcl6 deficiency impairs the lineage stability of Treg cells by down-regulating the histone H3K4 trimethylation. Importantly, Bcl6 inhibition repressed the tumor growth of murine HNSCC and exhibited synergistic effects with immune checkpoint blockade therapy. These findings suggest that Bcl6 can be exploited as a promising therapeutic target for HNSCC treatment.

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Publication Details

Journal
Genes & Diseases
Published
2024-12-26
DOI
https://doi.org/10.1016/j.gendis.2024.101505
Citations
1
Primary Topic
T-cell and B-cell Immunology
Type
article
Field-Weighted Citation Impact
0.24

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article

Bcl6 controls the stability and suppressive function of regulatory T cells in head and neck squamous cell carcinoma

Zhengliang Yue, Lifan Xu, Mengqu Ran, Junyi Guo et al.
1 citations
Genes & Diseases
T-cell and B-cell Immunology
0.24
article

Bcl6 controls the stability and suppressive function of regulatory T cells in head and neck squamous cell carcinoma

Zhengliang Yue, Lifan Xu, Mengqu Ran, Junyi Guo, Xingxing Su, Lilin Ye, Yuzhu Wang, Lisha Wang, Jianjun Hu, Zhanpeng Ou, Jing Zhao, Qizhao Huang, Ping Ji, Ling Ran, Shuqiong Wen, Qinyi He, Zhiyu Chen
article en
1 citations

Abstract

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common cancer globally. Most studies in HNSCC demonstrated that regulatory T (Treg) cells confine the anti-tumor activity of effector T cells which may contribute to the immune escape and uncontrolled tumor progression. Here, we uncovered that the specific abrogation of Bcl6 in Treg cells resulted in significantly delayed malignant transformation of 4NQO-induced tumorigenesis. Bcl6 deficiency impairs the lineage stability of Treg cells by down-regulating the histone H3K4 trimethylation. Importantly, Bcl6 inhibition repressed the tumor growth of murine HNSCC and exhibited synergistic effects with immune checkpoint blockade therapy. These findings suggest that Bcl6 can be exploited as a promising therapeutic target for HNSCC treatment.

Genes & DiseasesVol. 12(4)
Central South University (CN), Army Medical University (CN), Guangdong Province Stomatological Hospital (CN), Stomatological Hospital of Chongqing Medical University (CN), Southwest Hospital (CN), Stomatology Hospital (CN), Third Xiangya Hospital (CN), Chongqing Medical University (CN)
National Science Foundation, National Natural Science Foundation of China, Natural Science Foundation of Chongqing, Southwest Hospital, Centre Scientifique et Technique du Bâtiment
Openalex Percentile: Top 39%
T-cell and B-cell Immunology
0.24
DOIOpen Access PDFOpenAlex
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