Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells
Collectively, our results revealed a previously unidentified molecular mechanism regulating the synthesis of monounsaturated fatty acids corroborating the notion that novel therapeutic approaches that include CK2 targeting, may offer a greater synergistic anti-tumour effect for cancers that are highly dependent on fatty acid metabolism.
Authors
- Brage Storstein Andresen (ORCID: https://orcid.org/0000-0001-7488-3035)
- Thomas Koed Doktor (ORCID: https://orcid.org/0000-0002-5315-8325)
- Scott E. Roffey (ORCID: https://orcid.org/0000-0001-9777-4106)
- Laszlo Gyenis (ORCID: https://orcid.org/0000-0003-4689-9480)
- Aarif Siddiqui (ORCID: https://orcid.org/0000-0003-4308-3398)
- Samantha L. Cousineau
- Bárbara Guerra (ORCID: https://orcid.org/0000-0003-1136-2413)
- Kristina Jurčić
- David W. Litchfield (ORCID: https://orcid.org/0000-0002-2425-6620)
- Caroline A. Lindegaard (ORCID: https://orcid.org/0009-0007-4708-0924)
- Arturo González Ferrer
- Laura M. Buchwald
- Rachelle van der Poel
Institutions
- Western University (CA)
- University of Southern Denmark (DK)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s12935-024-03611-y
- Citations
- 4
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Novo Nordisk
- Novo Nordisk Fonden