Photoredox-Catalyzed Aminolactonization of 2-Styrylbenzoic Acids with <i>N</i>-Aminopyridinium Salts to Access 4-Sulfonamino-3,4-dihydroisocoumarins
A photoredox-catalyzed aminolactonization of unsaturated carboxylic acids was achieved using <i>N</i>-aminopyridinium salts as the amino radical precursor. The transformation features mild conditions and a remarkably broad substrate scope, offering an efficient approach to construct a wide range of 4-sulfonamino 3,4-dihydroisocoumarins. Mechanistic studies indicate that the reaction proceeds via a distinctive <i>N</i>-aminopyridinium salt-promoted electrophilic amination of 2-styrylbenzoic acids.
Authors
- Wei‐Shiung Lian (ORCID: https://orcid.org/0000-0003-3462-3620)
- Jinwei Yuan (ORCID: https://orcid.org/0000-0002-4226-1853)
- Liangru Yang (ORCID: https://orcid.org/0000-0001-8645-5505)
- Shouren Zhang (ORCID: https://orcid.org/0000-0001-6661-6324)
- Tong-Tong Bi
- Qiang Liu (ORCID: https://orcid.org/0000-0002-5451-4862)
- Wenyu Hu (ORCID: https://orcid.org/0000-0001-6508-897X)
- Yan Meng (ORCID: https://orcid.org/0009-0001-0185-4193)
Institutions
- Henan University of Technology (CN)
- Huanghe Science and Technology College (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1021/acs.joc.4c02473
- Citations
- 8
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Henan University of Technology
- Natural Science Foundation of Henan Province